The receptor status and NS were tabulated. The reduced hormone receptor expression might be one of the mechanism by which Her-2/neu positive tumors show a decreased response to hormonal agents and decreased DFS.Methods: The data on all women reviewed pathology reports Invasive ducat carcinoma of breast in our community hospital were retrospectively analyzed. Its over expression produces ligand independent down regulation of ER. Her-2/neu over expression is associated with features of a poor prognosis like high tumor grade and S- phase fraction, nodal metastasis and estrogen(ER) and progesterone receptor (PR) negativity. Hormones receptors (ER and PR) and Her-2/neu gene or its protein are now routinely evaluated in all breast cancer cases. Tumors are graded based on the combined score into grade I(3-5 well differentiated), grade II(6-7,moderately differentiated) and grade III(8-9 poorly differentiated). Objective: The Nottingham score(NS), a histological grading system for invasive breast carcinoma include by Tubule formation, Nuclear pleomorphism and Mitotic rate as criteria and each are assigned 1,2 or 3 points and the scores are added for a combined histological score.
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